Risk factors for leptomeningeal collateral circulation compensation in patients with AIS due to MCA stenosis after thrombolytic therapy
Abstract：Objective To study the risk factors for leptomeningeal collateral circulation (LMA)compensation in patients with acute ischemic stroke (AIS) due to middle cerebral artery (MCA)stenosis after thrombolytic therapy.Methods The LMA compensation was assessed by craniocervical CTA in 178 patients with AIS due to MCA stenosis after they underwent thrombolytic therapy with rt-PA.The patients were divided into poor LMA group (n=65) and good LMA group (n=113) according to their regional leptomeningeal score.Results The incidence of hypertension,the NIHSS score after 24 h and 10 days of thrombolytic therapy,the mRS score,the incidence of intracranial hemorrhage and mortality were significantly lower,the serum TG level and the outcome were significantly better in good LMA group than in poor LMA group after 90 days of thrombolytic therapy (P＜0.05,P＜0.01).Multivariate logistic regression analysis showed that hypertension,serum TG level,and old ischemic stroke were related with LMA compensation in AIS patients after thrombolytic therapy (OR=2.831,95 ％CI:1.100-7.287,P=0.031;OR=2.136,95％CI:1.026-4.448,P=0.034;OR=2.922,95 ％CI:1.096-7.789,P=0.032).Conclusion Hypertension does not help to establish LMA while serum TG level contributes to the growth of LMA in AIS patients due to MCA stenosis after thrombolytic therapy.Old ischemic stroke is an independent predictor for the poor LMA compensation.
Keywords：middle cerebral arterystroketissue plasminogen activatorcollateral circulation
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 918-921 )