Relationship between blood urea nitrogen level on admission and short-term clinical outcome in elderly AIS patients after thrombolytic therapy
Abstract：Objective To study the relationship between blood urea nitrogen (BUN) level on admission and short-term clinical outcome in elderly acute ischemic stroke (AIS) patients after thrombolytic therapy.Methods One hundred and ninety-two AIS patients admitted to our hospital from May 2014 to January 2016 for thrombolytic therapy with recombinant tissue plasminogen activator (rt-PA) were included in this study.Their clinical outcome was scored according to the mRS and considered as poor when the mRS score was 3-6 after 90 days of thrombolytic therapy.Relationship between BUN level and poor clinical outcome was analyzed by logistic regression analysis.Results Univariate logistic regression analysis showed that AF,BUN level and NIHSS score were related with poor clinical outcome in AIS patients.The risk of poor clinical outcome was relatively low in ischemic stroke due to small artery occlusion or unknown reasons (OR =0.106,95％CI:0.023-0.481,P=0.004;OR=0.378,95％CI:0.177-0.811,P=0.012).Mltivariate logistic regression analysis showed that BUN level,NIHSS score and AF were the independent risk factors for poor clinical outcome in AIS patients (OR=1.309,95 ％CI:1.080-1.587,P=0.006;OR=1.321,95％CI:1.205-1.447,P=0.000;OR=3.782,95％ CI:1.384-10.335,P=0.010).Conclusion The BUN level on admission is an independent risk factor for poor clinical outcome in elderly AIS patients after 90 days of thrombolytic therapy.
Keywords：ureastroketissue plasminogen activatoratrial fibrillationprognosis
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 910-913 )