Role of 5 risk scales in predicting symptomatic intracerebral hemorrhage and poor outcome in AIS patients after intravenous thrombolytic therapy
Abstract：Objective To study the role of 5 risk scales in predicting sICH and poor outcome in AIS patients after intravenous thrombolytic therapy.Methods Two hundred and two AIS patients admitted to our hospital for intravenous thrombolytic therapy with rt-PA were included in this study.Their symptomatic cerebral hemorrhage and poor outcome were scored according to the MSS,NIHSS,SPAN-100,SEDAN,THRIVE,and GRASPS.The role of 5 risk scales in predicting sICH and poor outcome in AIS patients after intravenous thrombolytic therapy was assayed according to the area under ROC (AUC).The patients were divided into low risk group (n=99) with their THRIVE score ≤3 and high risk group (n=103) with their THRIVE score ≥4.Results The AUC was ＜0.8 for the 5 risk scals in predicting sICH.The AUC was 0.833 and 0.813 respectively for the THRIVE in predicting the mortality and poor outcome in AIS patients after 90 days of intravenous thrombolytic therapy (95％ CI:0.768-0.893,95％ CI:0.754-0.872).The THRIVE score was higher in predicting the poor outcome in high risk group than in low risk group after 90 days of intravenous thrombolytic therapy (OR=11.498,95％CI:5.470-24.167,P＜0.01).Conclusion The role of 5 risk scales is limited in predicting sICH in AIS patients after intravenous thrombolytic therapy.The role of THRIVE is better than that of the other 4 scales in predicting the poor outcome in AIS patients after intravenous thrombolytic therapy.
Keywords：brain infarctiontissue plasminogen activatorcerebral hemorrhageprognosis
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 906-909 )