Role of inflammation in progressive abdominal aortic aneurysm in rabbits based on 18F-FDG PET/CT imaging
Abstract：Objective To study the relationship between progressive AAA and inflammation in rabbits according to their 18F-FDG PET/CT imaging.Methods An infrarenal AAA model of rabbits was established by intracavity elastase perfusion.Ten rabbits were killed at weeks 2 and 4 respectively after ultrasonography and PET/CT scanning.Ear venous blood samples were taken for detecting the expression of MMP-2 and MMP-9,artery tissue samples were taken for calculating the average standard uptake value,SUV and standard TBR with pathological and immunohistochemical staining.Results The maximal growth rate of aneurysm diameter was 89.21％±0.02％ higher at week 2 after ultrasonography and PET/CT scanning than before ultrasonography and PET/CT scanning and was 5.80％±0.01％ higher at week 4 after ultrasonography and PET/CT scanning than at week 2 after ultrasonography and PET/CT scanning.The expression levels of MMP-2 and MMP-9 were significantly higher at week 4 after ultrasonography and PET/CT scanning than at week 2 after ultrasonography and PET/CT scanning (P＜0.05) and were significantly lower at week 4 after ultrasonography and PET/CT scanning than at week 2 after ultrasonography and PET/CT scanning (P＜0.05).The SUVmax was significantly lower at week 4 after ultrasonography and PET/CT scanning than at week 2 after ultrasonography and PET/CT scanning (P＜0.05).The rate of stained macrophage area was significantly higher at week 2 after ultrasonography and PET/CT scanning than at week 4 after ultrasonography and PET/CT scanning (P＜0.05).Conclusion Inflammation plays an important role in early progressive AAA.
Keywords：fluorodeoxyglucose F18positron-emission tomographyaortic aneurysmabdominal
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 853-857 )