Efficacy and safety of statins in very old coronary heart disease patients
Abstract：Objective To study the efficacy and safety of statins (atorvastatin,pravastatin,rosuvastatin) in very old coronary heart disease (CHD) patients.Methods One hundred and seventy-four ≥ 80 years old CHD patients admitted to our hospital were divided into atorvastatin (20 mg/d) treatment group (n=58),pravastatin (40 mg/d) treatment group (n=55),and rosuvastatin (10 mg/d) treatment group (n=61).Their serum levels of lipid,ALT,Scr,CK were measured and the incidence of cardiovascular and cerebrovascular events was recorded before and 6 months after treatment.Results The serum levels of LDL-C and non-HDL-C were significantly higher in 3 statin treatment groups before treatment than after treatment (31.03％ vs 15.52％,21.82％ vs 7.27％,27.87％ vs 9.84％,P＜0.05;58.62％ vs 37.93％,43.64％ vs 25.45％,65.57％ vs 31.15％,P＜0.05).The incidence of major cardiovascular and cerebrovascular events was 18.97％,23.64％ and 16.39％ respectively and the mortality was 5.17％,5.45％ and 4.92％ respectively in 3 statin treatment groups 12 months after treatment (P＞0.05).Conclusion Moderate dose of atorvastatin,pravastatin and rosuvastatin can effectively and safely reduce the serum lipid level in very old CHD patients.
Keywords：coronary diseasedyslipidemiasatherosclerosisantilipemic agentsalanine transaminasefisk factors
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 829-832 )