Relationship between methylene reductase C677T gene polymorphism and isolated systolic hypertension in elderly people
Abstract：Objective To study the relationship between 5,10-methylene reductase (MTHFR) gene C677T polymorphism and isolated systolic hypertension (ISH) in elderly people.Methods Two hundred and twenty ISH patients aged ≥60 years served as an ISH group and 128 hypertension-free elderly people undergoing physical examination served as a control group in this study.Their MTHFR gene C677T polymorphism was detected and their serum homocysteine level was measured.Results The frequency of T allelic gene was higher and that of C allelic gene was lower in ISH group than in control group (51.8％ vs 37.5 ％,x2 =13.33,P=0.000;48.2％ vs 62.5％,x2=13.33,P=0.000).The distribution rate of C/C genotype was lower and that of C/T genotype was higher in ISH group than in control group (20.5％ vs 40.6％,x2 =16.38,P=0.000;55.5％ vs 43.8％,x2 =4.44,P=0.035).The serum homocysteine level was higher in ISH group than in control group (P=0.01).Logistic regression analysis showed that MTHFR gene C677T polymorphism and serum homocysteine and uric acid levels were the independent risk factors for ISH in elderly people (OR=1.910,95％CI:1.356-1.910,P=0.00;OR=1.084,95％CI:1.084-1.084,P=0.02;OR=1.004,95％CI:1.001-1.006,P=0.01).Conclusion MTHFR gene C677T polymorphism and serum homocysteine level are the independent risk factors for ISH in elderly people.
Keywords：methylene tetrahydrofolate reductase (NADPH2)homocysteinehypertensiongene frequencygenotypeuric acid
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 821-824 )