Serum perilipin 5 level and its relative factors in coronoary heart disease patients
Abstract：Objective To study the association between serum perilipin 5 level and coronoary heart disease (CHD).Methods One hundred and thirteen CHD patients including 55 with acute coronary syndrome (ACS) and 58 with stable angina pectoris (SAP) served as a CHD group,and 113 age-and gender-matched CHD-free persons served as a control group in this study.Their serum perilipin 5 levels were measured by ELISA.Association between serum perilipin 5 level and risk factors for CHD was analyzed by multivariate logistic regression analysis.Results The serum perilipin 5 level was significantly lower in CHD group than in control group and in ACS patients than in SAP patients (2.69 μg/L vs 4.29 μg/L,P＜0.01;2.30 μg/L vs 3.29 μg/L,P＜0.01).Spearman correlation analysis showed that serum perilipin 5 level was positively associated with serum HDL-C level (r=0.186,P＜0.01).Multivariate logistic regression analysis showed that low serum perilipin 5 level was an independent risk factor for CHD (OR=0.736,95％CI:0.603-0.898,P=0.003).Conclusion The serum perilipin 5 level is low in CHD patients.Low serum perilipin 5 level is an independent risk factor for CHD and can thus be used as a biochemical indicator for CHD.
Keywords：coronary diseaseacute coronary syndromeangina pectoriscoronary angiographyrisk factors
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 816-820 )