Serum uric acid and 25 hydroxyl vitamin D3 levels in Parkinson's disease patients
Abstract：Objective To study the relationship of serum uric acid (UA) and 25 hydroxyl (OH) vitamin D3 levels with Parkinson's disease (PD).Methods One hundred and six PD patients admitted to our hospital from August 2014 to August 2016 served as a PD group and 108 healthy persons undergoing physical examination served as a control group in this study.Their baseline data (including age,gender,serum UA and 25 OH vitamin D3 levels) were recorded and compared.Results The serum UA and 25 OH vitamin D3 levels were significantly lower in PD group than in control group (263.24±105.02 μmol/L vs 304.11±79.31 μmol/L,P=0.002;27.14±6.45 μg/L vs 36.96±11.62 μg/L,P=0.001).Logistic regression analysis showed that age and serum levels of UA and 25 OH vitamin D3 were closely related with PD (OR=1.024,95 ％ CI:1.001-1.081,P =0.028;OR=0.996,95％CI:0.992-1.000,P=0.001;OR=0.890,95％CI:0.852-0.929,P=0.000).Conclusion The serum UA and 25 OH vitamin D3 levels are significantly lower in PD patients,high UA and 25 OH vitamin D3 levels are thus a protective factor for PD.
Keywords：Parkinson diseaseuric acidcalcifedioloxidative stress
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 806-808 )