Molecular imaging characteristics of dementia with Lewy bodies and Parkinson's disease with cognitive impairment
Abstract：Objective To study the molecular imaging characteristics of dementia with Lewy bodies (DLB) and Parkinson's disease with cognitive impairment (PD-CI).Methods Six DLB patients and 15 PD-CI patients admitted to our hospital from February 2014 to December 2016 were included in this study.Their clinical history,neuropsychological and 11C-β-CFT,11 C-PIB,11C-RAC,18F-FDG imaging characteristics were retrospectively analyzed.Results The rate of symmetrical reduction of 11C-β-CFT uptake on bilateral putamen,radioactive retention of 11C-PIB in extensive cerebral cortex and glucose metabolism reduction on connected area of parietal and occipital cortex was significantly higher while that of asymmetrical reduction of 11C-β-CFT uptake on bilateral putamen was significantly lower in DLB patients than in PD-CI patients (50.0％ vs 13.3％,80.0％ vs 16.7％,100.0％ vs 40.0％,P＜0.05;33.3％ vs 86.7％,P＜0.05).Of the 3 DLB patients who underwent 11C-RAC,1 (33.3 ％) showed a lower radioactive retention of 11C-RAC in bilateral putamen and 2 showed a higher radioactive retention of 11C-RAC in bilateral putamen.The 15PD-CI patients (100.0％) showed a high radioactive retention of 11C-RAC in bilateral putamen.Conclusion Molecular imaging can show the molecular characteristics of DLB and PD-CI,thus contributing to their differential diagnosis.
Keywords：Lewy body diseaseParkinson diseasecognition disordersneuropsychologyfluorode-oxyglucose F18positron-emission tomographyearly diagnosis
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 793-796 )