Relation of CD4CD25 regulatory T cell expression and carotid plaque nature with progressive ischemic stroke in elderly patients
Abstract：Objective To study the relation of CD4 CD25 regulatory T cell (Treg) expression and carotid plaque nature with progressive ischemic stroke in elderly patients.Methods Eighty-two elderly acute ischemic stroke (AIS) patients were divided into progressive AIS group (n=42) and non-progressive AIS group (n =40) according to their clinical symptoms and diagnostic criteria with 26 subjects undergoing physical examination served as a control group.Patients in AIS were further divided into stable plaque group and unstable plaque group according to their Doppler ultrasonographic findings.Expressions of Treg in progressive AIS group and non-progressive AIS group were detected by flow cytowetry and compared.Results The detection rate of unstable plaques was 57.1％ in progressive AIS group.The expression level of Treg was significantly low-er in progressive AIS group than in non-progressive AIS group and in unstable plaque group than in stable plaque group (7.256％±1.424％ vs 10.505％± 1.502％,P＜0.05;7.576％±1.452％ vs 10.352％ ± 1.516％,P＜0.05).Conclusion Treg expression and unstable plaques are related with progressive ischemic stroke.Treg expression is related with carotid plaque nature.
Keywords：T-lymphocytesregulatorycarotid artery diseasesbrain infarction
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 735-737 )