Relationship between cerebral microbleeds and ischemic stroke
Abstract：Objective To study the relationship between cerebral microbleeds (CMB) and serum homocysteine level in ischemic stroke (IS) patients in order to find the risk factors and biomarkers for recurrent IS.Methods Five hundred and forty IS patients were divided into first-ever IS group (n=188) and recurrent IS group (n=352) or into CMB group (n=146) and CMB-free group (n=394) according to their imaging data.Relationship of demographic data,vascular risk factors and serological parameters with CMB and recurrent IS was analyzed.The age to develop IS was also analyzed.Results The incidence of hypertension,SBP and serum homocysteine level were significantly higher while the serum TC level was significantly lower in CMB group than in CMB-free group (P＜0.05,P＜0.01).The age was significantly younger while the prevalence of smoking,SBP,DBP,serum levels of HbAIc,TC and LDL were significantly higher in first-ever IS group than in recurrent IS group (P＜0.05,P＜0.01).Multivariate logistic regression analysis showed that hypertension and serum homocysteine level were the independent risk factors for CMB while TC was the protective factor for CMB (OR =1.852,95％ CI:1.134-3.026,P =0.014;OR=1.012,95％ CI:1.001-1.023,P=0.037;OR=0.827,95％CI:0.732-0.935,P=0.002).First-ever IS was easy to occur in 45-65 years old patients.Conclusion CMB can prevent IS by regulating hypertension and serum levels of homocysteine and TC,and reduce the incidence of recurrent IS,especially that of hypertension and diabetes mellitus.
Keywords：cerebral hemorrhagebrain infarctionhomocysteinehypertensiondiabetes mellitus
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 615-618 )