Risk factors for bleeding in elderly patients with acute coronary syndrome undergoing combined PCI and tirofiban treatment
Abstract：Objective To study the risk factors for bleeding in elderly patients with acute coronary syndrome (ACS) undergoing combined PCI and tirofiban treatment.Methods One hundred and sixty-four ACS patients undergoing combined PCI and tirofiban treatment in our hospital from January 2014 to December 2015 were divided into ≥65 years old group (n=71) and ＜65 years old group (n=93).The incidence of bleeding was recorded in two groups according to the TIMI criteria,the risk factors for bleeding in ≥65 years old group were analyzed by logistic regression analysis.Results The incidence of bleeding,massive bleeding and minor bleeding was significantly higher in ≥65 years old group than in ＜65 years old group during combined PCI and tirofiban treatment (43.1％ vs 25.8％,P＜0.05;14.1％ vs 4.3％,P＜0.05).Multivariate logistic regression analysis showed that female,BMI and GFR were the independent risk factors for bleeding in ≥65 years old group during combined PCI and tirofiban treatment (OR=404.434,95 ％CI:1.767-92543.210,P=0.030;OR=0.817,95％CI:0.675-0.990,P=0.039;OR=1.185,95％CI:1.003-1.400,P=0.046).Conclusion The risk of bleeding is higher in ≥65 years old ACS patients than in ＜65 years old ACS patients.Female,decreased BMI and impaired renal function are the independent risk factors for bleeding in elderly ACS patients during combined PCI and tirofiban treatment.
Keywords：acute coronary syndromeplatelet aggregation inhibitorsplatelet glycoprotein GPⅡb-Ⅲa complexhemorrhagerisk factors
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 596-599 )