Factors influencing microcirculation resistance of left anterior descending coronary artery in elderly hypertensive patients
Abstract：Objective To study the factors influencing microcirculation resistance (IMR) of left anterior descending coronary artery in elderly hypertensive patients.Methods One hundred and forty-seven elderly patients with their coronary artery stenosis ＜50 ％ admitted to our hospital from July 2015 to August 2016 were divided into hypertension group (n=87) and control group (n=60).The IMR of their left anterior descending coronary artery was tested with Doppler guidewire.Their clinical data,biochemical and color cardiac ultrasonographic parameters,albumin/creatinine ratio (ACR),and left ventricular mass index (LVMI) were recorded.Factors influencing IMR were analyzed.Results The ACR and LVMI were significantly higher,the diastolic insufficiency was significantly severer,the baseline mean transit time at rest (bTmn) and hyperemia mean transit time (hTmn) were significantly longer,and the IMR was significantly greater in hypertension group than in control group (P＜0.05,P＜0.01).Multivariate logistic regression analysis showed that ACR,LVMI,and diastolic insufficiency were the risk factors for IMR in elderly hypertension patients (OR =4.12,95％CI:3.63-4.61,P =0.04;OR =1.99,95％ CI:1.75-2.23,P=0.03;OR=4.75,95％CI.4.48-5.02,P=0.04).Conclusion Elevated IMR of left anterior descending coronary artery is associsted with albuminuria myocar-dial hypertrophy,and diastolic insufficiency in elderly hypertensive patients.
Keywords：hypertensioncoronary vesselsmicrocirculationvascular resistancecoronary stenosis
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 588-591 )