Change trends of clinical characteristics, therapies and in hospital events in elderly patients with acute coronary syndrome
Abstract：Objective To study whether clinical characteristics,therapies and in-hospital events of elderly patients with acute coronary syndrome (ACS) changed over time.Methods This study enrolled 944 ACS patients aged ≥ 60 years hospitalized in Department of Cardiology,Peking University First Hospital,including 628 patients aged 60-74,316 patients aged 75-89,of them,162 patients in 2000,293 patients in 2007,489 patients in 2014,respectively.Temporal trends of clinical features,guideline-recommended therapies and in-hospital events were analyzed.Results From 2000 to 2014,patients were older,percentage of comorbidities such as hypertension,diabetes and hyperlipedemia increased (for hypertension,increased from 66.0％ to 75.5％,for DM,from 21.6％ to 43.1％,for hyperlipedemia,from 12.3％ to 44.0％).The proportion of patients who underwent previous CAG and PCI increased (for CAG,from 18.5％ to 40.9％,for PCI,from 8.0％ to 33.3％).Patients with symptomatic heart failure and infection at admission decreased.AMI patients took up a lesser proportion in 2007 and 2014,compared with those in 2000.UA patients increased markedly in 2014.Use of guideline-recommended drugs increased.PCI use increased from 34.6％ in 2000 to 70.6％ in 2014 (P＜0.01).Meanwhile,in-hospital mortality decreased from 11.1％ in 2000 to 1.6％ in 2014,and in-hospital MACCE from 21.6％ to 8.4％ (P＜0.01).Conclusion Clinical characteristics changed,use of guideline-recommended drugs and PCI increased over time,and in-hospital outcomes improved in elderly patients with ACS.
Keywords：acute coronary syndromehypertensiondiabetes mellitushyperlipidemiascoronary angiographydrug therapy
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 580-583 )