Association between serum hs-CRP level and renal function impairment in hypertensive patients
Abstract：Objective To study the association between serum hs-CRP level and renal function impairment in hypertensive patients.Methods Four hundred and ninety-six hypertensive patients admitted to our hospital from January 2016 to June 2016 were divided into normal renal function group (n=411) and impaired renal function group (n=85) according to their eGFR.Their body height,BMI,blood pressure and serum levels of BUN,Scr,LDL-C,HDL-C,TC,TG,hs-CRP were measured.Results No significant difference was found in gender,prevalence of CHD and DM,smoking history,BMI,and serum levels of TC,TG,HDL-C,LDL-C between the two groups (P＞0.05).The age was significantly older,the duration of hypertension was significantly longer,the serum levels of BUN,Scr and hs-CRP were significantly higher in impaired renal function group than in normal renal function group (62.44 ± 17.81 years vs 60.49 ± 14.40 years,P =0.014;7.30±5.90 years vs 6.10±4.70 years,P=0.021;6.53±1.88 mmol/L vs 4.21±1.60 mmol/L,P=0.000;137.50±42.48 μmol/L vs 78.67±21.71 μmol/L,P=0.000;4.63±2.41 mg/L vs 2.04±1.41 mg/L,P=0.000).Correlation analysis showed that eGFR was negatively associated with age,duration of hypertension,serum levels of BUN and Scr (r=-0.451,r=-0.564,r=-0.545,r=-0.794,P＜0.01).Conclusion Serum hs-CRP level is higher in hypertensive patients with renal function impairment.
Keywords：C-reactive proteinhypertensionrenal insufficiencyglomerular filtration rate
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 577-579 )