Association between serum growth differentiation factor-15 level and chronic heart failure

doi:10.3969/j.issn.1009-0126.2017.06.005

Abstract：Objective To study the association of serum GDF-15 level with the diagnosis and outcome of chronic heart failure (CHF).Methods Two hundred CHF patients served as an observation group and 100 healthy subjects served as a control group in this study.Their general clinical data and biochemical parameters were recorded,their serum GDF-15 and NT-proBNP levels were measured.The patients were followed up for 2 years,during which HF-related adverse events were recorded.Association between the role of serum GDF-15 level in diagnosis of CHF and the outcome of CHF patients was analyzed according to the ROC curve.Results The serum GDF-15 level was significantly higher in observation group than in control group (1629.3 ng/L vs 839.7 ng/L,P＜0.05) and was positively associated with the serum NT-proBNP level and heart function in observation group (r=0.682,r=0.326,P＜0.05).The area under the ROC curve for serum GDF-15 and NT-proBNP level in diagnosis of CHF was 0.823 and 0.766 respectively (P =0.00).The area under the ROC curve for combined GDF-15 and NT-proBNP was 0.829,which was higher than that either for GDF-15 or for NT-proBNP (P＜0.05).During the follow-up period,the incidence of adverse events was 49.0％ in observation group.The combined serum NT-proBNP and GDF-15 levels were significantly better than single serum GDF-15 or NT-proBNP level for the diagnosis of CHF (P＜0.05).Conclusion Serum GDF-15 level plays a certain role in diagnosis of CHF and assessment of its outcome,and plays a greater role when it is used in combination with NT-proBNP.