Therapeutic effect of urapidil injection in elderly hypertension patients with acute heart failure
Abstract：Objective To study the therapeutic effect of urapidil in elderly hypertension patients with acute heart failure (AHF).Methods One hundred and forty elderly hypertension patients with AHF were randomly divided into urapidil treatment group (n=70) and nitroglycerin treatment group (n=70).Their SBP,DBP and HR were recorded before and on days 1,2 and 3 after treatment,their serum NT-proBNP level and LVEF were measured before and on day 2 after treatment.Results The SBP and DBP were significantly lower and the HR was significantly slower in urapidil treatment group on days 1,2 and 3 after treatment than before treatment (135.33±20.63 mm Hg,127.13± 16.67 mm Hg,123.86 ± 11.54 mm Hg vs 159.84± 31.73 mm Hg;73.00±12.85 mm Hg,70.10±10.09 mm Hg,67.86±7.03 mm Hg vs 83.84±17.32 mm Hg;78.53±15.73/min,75.90±14.86/min,74.09±11.26/min vs 85.99±19.66/min,P＜0.05).The serum NT-proBNP level was significantly lower in urapidil treatment group on day 2 after treatment than before treatment (2858.81±4264.48 ng/L vs 4978.10±6772.53 ng/L,P＜0.05).Conclusion Urapidil can significantly reduce the blood pressure,stabilize the HR and improve the cardiac function in elderly hypertension patients with AHF.
Keywords：hypertensionheart failurenitroglycerinurapidil
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 566-568 )