Role of electronic pen in diagnosis of Parkinson's disease and assessment of early and intermediate motor symptom
Abstract：Objective To study the role of electronic pen in diagnosis of Parkinson's disease (PD) and its movement symptoms according to the movement parameters collected with electronic pen.Methods Thirty-nine PD patients (4 at prodromal statge,28 at Hoehn-Yahr 1.0-2.5 stage and 7 at Hoehn-Yahr 3.0 intermediate stage) served as a PD group,40 education-,sex-and agematched healthy subjects served as control group in this study.Their clinical data collected with electronic pen were compared with the movement parameters collected with computer (movement velocity,movement acceleration,movement time,tremor amplitude and tremor frequency).Results The mean movement velocity,movement acceleration,tremor frequency of upper extremities were significantly lower while the movement time and tremor amplitude of upper extremities were significantly higher in PD group than in control group (2.3±0.4 vs 3.0±0.8,1.4±0.2 vs 1.7± 0.2,4.2±1.7 vs 5.8±1.1,P=0.000;16.9±3.3 vs 13.7±2.4,4.3±1.8 vs 2.4±0.5,P=0.000).The parameters of bradykinesia and tremor were positively related with the MDS-UDPRS ]Ⅲ score and Hoehn-Yahr stage in PD group (r=0.8131,0.7809,P＜0.05).Conclusion Quantitative analysis of electronic pen trajectory can effectively detect dyskinesia and predict the severity of prodromal,early and intermediate PD,and is thus a more rapid,sensitive,simple,objective and promising tool than MDS-UPDRS for diagnosis of dyskinesia and PD.
Keywords：Parkinson diseasemovement disordersearly diagnosiselectronic pen
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：7( 496-502 )