Curative effect of nicorandil in very old patients with multiple coronary branch lesions and chronic heart failure
Abstract：Objective To study the curative effect of nicorandil in very old patients with multiple coronary branch lesions and chronic heart failure (CHF).Methods Ninety-six very old patients with multiple coronary branch lesions and CHF admitted to our hospital from January 2012 to July 2016 were randomly divided into experimental group (n=48) and control group (n=48).Patients in experimental group were treated with oral nicorandil (5 mg,3 times a day) while those in control group were treated with isosorbide mononitrate (20 mg,twice a day) in addition to conventional treatment.Their serum B-type natriuretic (BNP) level,LVEF,left ventricular end-diastolic diameter (LVEDD) and left ventricular end-systolic diameter (LVESD) were measured before and after treatment.The curative effect and adverse reaction were compared between the 2 groups after 6 months of treatment.Results The significant efficacy and total effective rate of nicorandil for angina pectoris and cardiac function were significantly higher in experimental group than in control group after 6 months of treatment (31.3 ％ vs 10.4 ％,83.3 ％ vs 60.4 ％,P＜0.05;31.3％ vs 14.6％,75.0％ vs 54.2％,P＜0.05).The LVEF was significantly higher while the serum BNP level was significantly lower,the LVESD and LVEDD were significantly shorter in experimental group than in control group after 6 months of treatment (P＜0.05).Conclution Nicorandil can effectively reduce the risk of angina pectoris and improve the cardiac function in very old patients with multiple coronary branch lesions and CHF.
Keywords：nicorandilcoronary artery diseaseheart failureangina pectorisnatriuretic peptidebrainventricular functionleft
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 479-482 )