Relationship between hyperuricemia and metabolic syndrome in elderly males and females

doi:10.3969/j.issn.1009-0126.2017.05.004

Abstract：Objective To study the relationship between hyperuricemia and metabolic syndrome (MS) in elderly males and females.Methods A total of 911subjects (409 males and 502 females) aged ≥60 years,selected during the investigation of risk factors for chronic diseases in Changping District of Beijing,were divided into hyperuricemia group and normal uric acid group.A case control study was performed.Results The incidence of hyperuricemia was 11.30％ in the 911 subjects included in this study with no significant difference found between males and females (11.5％ vs 11.2％,x2 =0.025,P=0.916).The incidence of MS was 60.6％ in these subjects and was significantly lower in males than in females (44.3％ vs 67.2％,x2=82.978,P=0.000).The incidence of hyperuricemia increased with the number of MS components (5.3％ vs 7.9％ vs 9.6％ vs 8.2％ vs 16.2％ vs 17.5％,x2 =15.384,P=0.009).The ratio of female hyperuricemia patients with MS was significantly higher than that of those without hyperuricemia but with MS (85.7％ vs 72.4％,x2 =4.558,P=0.033) with no significant difference found in males.Hyperuricemia was an independent risk factor for MS after adjustment for other factors (OR=2.350,95％CI:1.020-5.416,P=0.045).Conclusion Hyperuricemia is closely related with MS in females.Active intervention of hyperuricemia can thus control the occurrence and progression of MS and reduce the risk of cardiovascular and cerebrovascular events.