Relationship of serum uric acid level with metabolic syndrome and chronic kidney disease in elderly residents of Beijing communities
Abstract：Objective To study the relationship of serum uric acid (UA) level with metabolic syndrome (MS) and chronic kidney disease (CKD) in elderly residents of Beijing communities.Methods A total of 1419 elderly subjects from 3 Beijing communities who underwent physical examination were included in this study.Their waist circumference,blood pressure,and serum levels of blood glucose,TC,TG,HDL-C,LDL-C,UA,urea nitrogen and creatinine were measured and their glomerular filtration rate (eGFR) was assayed.Relationship of serum UA level with MS and CKD was analyzed.Results The age was older,the SBP and DBP,the prevalence of smoking and the serum low HDL-C level were higher while the prevalence of obesity,the serum levels of TG and high LDL-C,the incidence of hyperuricemia and MS were lower in males than in females (P＜0.01).No significant difference was found in the prevalence of CKD between men and women (P=0.283).The serum UA level was positively related with the serum urea nitrogen and creatinine level (rmale=0.148,rfemale =0.247,P＜0.01;rmale =0.495,rfemale =0.514,P＜0.01) and was negatively related with eGFR in both males and females (rmale =-0.358,rfemale =-0.416,P＜0.01).Logistic regression analysis showed that age and hyperglycemia were the independent risk factors for CKD in both males and females.Conclusion Hyperuricemia is an important risk factor for CKD.However,MS is not related with CKD.
Keywords：uric acidmetabolic diseasesnephrosisglomerular filtration ratehyperuricemia
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 452-456 )