Short-term outcome and safety of intravenous thrombolysis in isolated pontine infarction patients
Abstract：Objective To study the short-term outcome and safety of intravenous thrombolysis in isolated pontine infarction patients within 4.5 h after onset.Methods Of the 605 patients admitted for intravenous thrombolysis,29 with MRI-confirmed isolated pontine infarction served as a pontine infarction group and 59 with MRI-confirmed basal ganglia infarction served as a basal ganglia infarction group.Their clinical characteristics,risk factors,laboratory findings,modified Rankin Scale score≤2 at discharge and on day 90 after discharge,incidence of intracranial and extracranial hemorrhage were analyzed.The progression or fluctuation of neurological deterioration after intravenous thrombolysis was observed in isolated pontine infarction patients.Results The serum fibrinogen level was significantly higher in pontine infarction group than in basal ganglia infarction group (P＜0.05).No significant difference was found in outcome at discharge and on day 90 after discharge between the two groups (P＞0.05).Of the 29 pontine infarction patients,12 were diagnosed with neurological deterioration or fluctuation (6 with a good outcome at discharge and 1 with a poor outcome on day 90 after discharge).Conclusion Intravenous thrombolysis is effective and safe for hyperacute isolated pontine infarction patients.Although the incidence of neurological deterioration or fluctuation is high after intravenous thrombolysis,the short-term outcome is rather good in isolated pontine infarction patients.
Keywords：brain infarctionthrombolytic therapyfibrinogenprognosis
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 395-398 )