Prevalence and risk factors of aspirin resistance in elderly patients with hypertension
Abstract：Objective To study the prevalence and risk factors of aspirin resistance (AR) in the elderly hypertensive patients.Methods Five hundred and forty-seven hypertensive patients aged ＞ 65 years admitted to our hospital were divided into aspirin resistant (AR) group (n=41),aspirin semi-resistant (ASR) group (n=219) and aspirin sensitive (AS) group (n=287) according to their platelet aggregation induced by AA and ADP.After the patients were given 100 mg aspirin for ≥ 2 months,their platelet function was tested by light transmission aggregometry,their clinical data and laboratory blood test parameters were recorded.Results The prevalence of AR was 7.5％.The platelet aggregation induced by AA and ADP,the serum levels of Hcy,NT-proBNP,hs-CRP,TC and LDL-C were significantly higher in AR group and ASR group than in AS group (P＜ 0.01).Logistic regression analysis showed that the serum levels of LDL-C,hs-CRP,NT-proBNP,and Hcy were positively related with the prevalence of AR (OR =2.911,P=0.000;OR=5.946,P=0.000;OR=1.012,P=0.000;OR=1.704,P=0.000).Conclusion The prevalence of AR is higher in elderly hypertensive patients.Higher serum levels of LDL-C,hs-CRP,NT-proBNP and Hcy are the risk factors for AR,and it is necessary to strengthen their prevention and intervention.
Keywords：hypertensionaspirinplatelet aggregationhomocysteineC-reactive protein
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 366-369 )