Effect of lower nutritional state on mild to moderate Alzheimer's disease with positive β-amyloid plaque imaging
Abstract：Objective To study the effect of lower nutritional state on mild to moderate AD with positive β-amyloid plaque imaging.Methods Forty AD patients who visited the outpatient department of our hospital from December 2015 to October 2016 served as an AD group and 60 age-,sex-and education-matched subjects served as a control group in this study.Their serum total protein (TP),total homocysteine,albumin,vitamin B12,folate acid levels and BMI were measured,their vascular risk factors were detected,and the influencing factors of AD were analyzed by multivariate logistic regression analysis.Results The serum TP and vitamin B12 levels and the BMI were significantly lower in AD group than in control group (69.23±3.28 g/L vs 72.49±5.44 g/L,415.76±192.71 ng/L vs 545.24±316.86 ng/L,22.77±2.70 kg/m2 vs 24.67±3.59 kg/m2,P＜ 0.05,P＜0.01).Lower serum TP and folate acid levels and BMI were independently associated with AD after adjustment of age,sex,education and vascular risk factors (OR=0.846,0.833,0.817,P＜0.05,P＜0.01).Conclusion Lower nutritional level exacerbates the occurrence and progression of AD.Investigation of nutritional status in middle-aged and old-aged persons,especially in low and moderate income areas,may thus play an important role in preventing AD.
Keywords：Alzheimer diseasemalnutritionamyloid beta-proteinfolic acidbody mass index
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 345-348 )