Effect of rovastatin and ghrelin on metabolism of blood glucose and blood lipids in rats
Abstract：Objective To study the effect of rovastatin and ghrelin on blood glucose,blood lipids,BMI,ICAM 1 and VCAM-1 in rat model of abnormal blood glucose and blood lipids metabolism.Methods Forty healthy male Wistar rats were randomly divided into control group,model group,rovastatin treatment group and ghrelin treatment group (10 in each group).After the animals were fed with a high-fat diet for 12 weeks,their serum blood lipids,blood glucose,hs-CRP levels and BMI were measured.Expressions of ICAM-1 and VCAM-1 were detected by Western blot.Results The BMI,serum blood glucose,LDL-C,TC,hs-CRP levels,ICAM-1 and VCAM-1 expression levels were significantly higher in model group,rovastatin treatment group and ghrelin treatment group than in control group (P＜ 0.05,P＜0.01).However,the serum blood glucose level and BMI were significantly lower in ghrelin treatment group than in rovastatin treatment group (9.89±6.32 mmnol/L vs 17.56±3.56 mmol/L,289.62±32.66 g vs 358.72±30.89 g,P＜ 0.01).Conclusion The effect of ghrelin on blood lipids and inflammation is similar with that of rovastatin and is better than that of rovastatin on blood glucose and BMI.
Keywords：cell adhesion moleculesvascular cell adhesion moleculc-1diabetes mellitusghrelinantilipemic agents
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 305-307 )