Clinical features of gastric cancer patients with ischemic stroke as their initial manifestation
Abstract：Objective To study the clinical features of gastric cancer patients with ischemic stroke as their initial manifestation and its underlying pathogenesis.Methods Sixteen gastric cancer patients with ischemic stroke as their initial manifestation served as a gastric cancer group and 64 age-and sex-matched ischemic stroke patients served as a control group in this study.Their clinical data were retrospectively analyzed.Results The pathogenesis was unknown in 12 (75.0％) and ≥2 ischemic stroke foci involving different artery blood supply areas were detected in 10 out of the 16 gastric cancer patients.The hemoglobulin level was significantly lower,the prothrombin time was significantly longer,and the serum levels of CEA,AFP and D-dimer were significantly higher in gastric cancer group than in control group (P＜0.05).Logistic regression analysis showed that prolonged prothrombin time and elevated serum D dimer level were the independent risk factors for gastric cancer patients with ischemic stroke as their initial manifestation (OR=1.640,95％CI:1.031-2.608,P=0.037;OR=1.210,95％CI:1.180-1.260,P=0.000).Conclusion Gastric cancer patients with ischemic stroke as their initial manifestation are characterized by multiple ischemic stroke foci which are possibly related with gastric cancer-induced hypercoagulability.
Keywords：brain infarctionstomach neoplasmsprothrombin timecarcinoembryonic antigen
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 269-272 )