Risk factors of acute post-stroke depression at high altitude

doi:10.3969/j.issn.1009-0126.2017.02.016

Abstract：Objective To study the incidence and risk factors of acute post-stroke depression (PSD) in stroke patients at high altitude.Methods One hundred and sixty patients with acute cerebral hemorrhage and atherosclerotic ischemic stroke admitted to our hospital from different high altitudes were divided into PSD group (n=39) and PSD-free group (n=121).Their HDRS17,NIHSS,PSQI scores were recorded.Their serum hs-CRP,IL-6 and TNF-α levels were measured by scattering turbidimetry and ELISA respectively.The risk factors of acute PSD at different high altitudes were analyzed.Results The total incidence of acute PSD was 24.4％,no significant difference was found in the incidence of acute PSD between 2200 and 3000 meters altitude.Female,NIHSS score,serum level of hs-CRP,IL-6 and TNF-α were the risk factors of acute PSD.The serum levels of hs-CRP,IL-6 and TNF-α were significantly higher in PSD patients from 3000 meters altitude than in those from 2200 meters altitude (5.37±1.90 mg/L vs 3.93±1.53 mg/L,18.34±3.21 ng/L vs 16.33±2.77 ng/L,81.94±9.63 ng/L vs 74.70±8.05 ng/L,P＜0.05).The HDRS17 and PSQI scores were significantly higher in PSD patients from 3000 meters altitude than in those from 2200 meters altitude (18.62±3.54 vs 15.21±4.85,15.75±3.90 vs 12.36±5.02,P＜0.05).Conclusion The incidence of acute PSD at high altitude is similar to that in plain areas.Female,NIHSS score,serum hs-CRP,IL-6 and TNF-α levels are the risk factors of acute PSD.Inflammation and sleep quality play a certain role in the occurrence of acute PSD.