Protective effect of rhBNP on cardiac and renal function in acute myocardial infarction patients undergoing primary PCI
Abstract：Objective To study the protective effect of rhBNP on cardiac and renal function in AMI patients with ST-segment elevation undergoing primary PCI.Methods Ninety AMI patients with ST-segment elevation who underwent PCI were randomly divided into treatment group (n=44)and control group (n=46).Their infarction size and serum Cr and Cys-C levels were measured,their cardiac and renal functions were assessed,and the incidence of contrast-induced nephropathy (CIN) was recorded.Results The QRS score was significantly lower and the infarction size was significantly smaller in treatment group and control group on days 1 and 7 after PCI than before PCI (P＜0.05).The LVEDD was significantly shorter and the LVEF was significantly higher in treatment group on day 7 after PCI than before PCI (P＜0.05).The QRS score was significantly lower and the infarction size was significantly smaller in treatment group than in control group on days 1 and 7 after PCI while the LVEDD was significantly shorter and the LVEF was significantly higher in treatment group on day 7 after PCI (P＜0.05).The serum Cr and Cys-C levels were significantly higher in treatment group than in control group on day 1 after PCI and in control group on days 1 and 2 after PCI (P＜0.05) and were significantly lower in treatment group than in control group on days 2 and 3 after PCI (P＜0.05).The incidence of CIN was significantly lower in treatment group than in control group (4.5％ vs 19.6％,P＜0.05).Conclusion rhBNP can reduce the myocardial infarction size and the incidence of CIN,and protect the cardiac and renal function in AMI patients with ST-segment elevation.
Keywords：natriuretic peptidebrainmyocardial infarctioncontrast mediamyocardial reperfusion
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 156-159 )