Curative effect and safety of levosimendan in elderly patients with acute decompensated heart failure due to ischemic cardiomyopathy
Abstract：Objective To study the curative effect and safety of levosimendan in elderly patients with acute decompensated heart failure (HF) due to ischemic cardiomyopathy.Methods Sixty elderly patients with acute decompensated HF due to ischemic cardiomyopathy were randomly divided into levosimendan treatment group and conventional treatment group (30 in each group).Their blood pressure,heart rate,left ventricular ejection fraction (LVEF),serum N-terminal proBNP and creatinine levels were measured before and 1 week after treatment.The curative effect and safety of levosimendan were compared in the patients.Results The LVEF was significantly higher and the serum N-terminal proBNP level was significantly lower in levosimendan treatment group than in conventional treatment group (36.5％ vs 34.0％,1872.9 ng/L vs 2499.6 ng/L,P＜0.05).No significant difference was found in blood pressure,heart rate and serum creatinine level between the two groups (P＞0.05).Conclusion The LVEF is higher and the serum N-terminal proBNP level is lower in elderly patients with acute decompensated HF due to ischemic cardiomyopathy after levosimendan treatment with no change in their blood pressure,heart rate and renal function,suggesting that levosimendan is safe and effective in elderly patients with acute decompensated HF due to ischemic cardiomyopathy.
Keywords：myocardial ischemiaheart failurestroke volumetroponin
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 153-155 )