Relationship between white matter ischemic lesion severity and serum cystatin C level in very old patients
Abstract：Objective To study the relationship between white matter ischemic lesion (WMIL) severity and serum cystatin C (Cys-C) level in ＞85 years old patients.Methods One hundred and fifteen WMIL patients were divided into mild WMIL group (n=42),moderate WMIL group (n=42) and severe WMIL group (n =31).Their age,history of hypertension,DM,nephrosis,CHD,cronic bronchitis,hyperlipidaemia,lacuna stroke and serum levels of SCr,BUN,Cys-C,creatinine and urea were recorded.Relationship between WMIL severity and serum Cys-C level was analyzed by multivariate logistic regression analysis.Results The incidence of DM was significantly higher in moderate WMIL group and severe WMIL group than in mild WMIL group (P＜0.05,P＜0.01).The serum Cys-C level was significantly higher in severe WMIL group than in mild WMIL group and moderate WMIL group (1.7±1.8 mg/L vs 0.7±0.6 mg/L,1.7±1.8 mg/L vs 0.9±0.6 mg/L,P＜0.05).Multivariate logistic regression analysis showed that serum Cys-C level was an independent risk factor for the WMIL severity after adjustment for age,history of hypertension and DM (OR =2.743,95 ％CI:0.497-1.527,P =0.000).Spearman correlation analysis revealed that elevated serum Cys-C level was positively related with the WMIL severity (r=0.344,P=0.000).Conclusion Elevated serum Cys-C level is related with the WMIL severity in very old patients.
Keywords：cysteine proteinase inhibitorsmagnetic resonance angiographyhypertensiondiabetes mellitusleukoaraiosisperfusion
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 63-66 )