Effect of continuous positive airway pressure on ambulatory blood pressure and cardio-cerebrovascular events in elderly OSA patients
Abstract：Objective To study the effect of continuous positive airway pressure (CPAP) on 24 h ambulatory blood pressure (ABP) and cardiao-cerebrovascular events (CCE) in elderly ischemic stroke patients with OSA and analyze the risk factors for CCE.Methods One hundred and fortyfive elderly ischemic stroke patients aged 60-80 (68.5 ± 7.3) years admitted to our hospital from May 2012 to May 2015 were randomly divided into CPAP group (n=73) and control group (n=72).Their 24 h ABP was measured.The patients were followed up for 1 year.Their survival time was analyzed by Kaplan-Meier survival analysis.The risk factors for CCE were predicted according to their ROC curve.Results The 24 h SBP and DBP,day SBP and DBP,and night DBP were significantly different between the two groups before discharge (P＜0.05).Kaplan-Meier survival analysis showed no significant difference in survival time between the two groups (365 d vs 362 d,P＞0.05).The incidence of CCE was significantly lower in CPAP group than in control group (21.9％ vs 33.3％,P＜0.05).The area under the ROC curve forAHI and 24 h SBP (0.70,95％CI:0.61-0.77,P=0.002;0.72,95％CI:0.63-0.81,P=0.003) were the risk factors for CCE.Conclusion CPAP can effectively reduce the 24 h ABP and the incidence of CCE in elderly ischemic stroke patients with OSA.
Keywords：continuous positive airway pressurebrain infarctionsleep apneaobstructiveblood pressure monitoringambulatoryROC curve
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 55-59 )