Protective effect of repeated noninvasive limb ischemia postconditioning on cerebral ischemia in rats
Abstract：Objective To study the protective effect of repeated remote noninvasive limb ischemia postconditioning on cerebral ischemia in rats .Methods Ninety male SD rats w ere randomly divid‐ed into sham operation group ,I/R injury group ,and repeated postconditioning (RPC) group (30 in each group) .Rats in RPC group received noninvasive limb ischemia postconditioning once a day . Nerve function in each group was scored .Apoptosis of neurons and hs‐CRP level in hippocampal CA1 were measured .Results The nerve function score and serum hs‐CRP level were significantly lower in RPC group than in I/R injury group on days 1 ,3 ,6 ,10 ,and 15 (11 .00 ± 1 .41 vs 15 .50 ± 1.38,11.17±0.98 vs15.17±0.98,8.00±1.26 vs14.83±1.94,7.17±0.98 vs12.67±1.03, 7 .50 ± 1 .76 vs 11 .67 ± 1 .63 ,P<0 .05) .Conclusion Repeated noninvasive limb ischemia postcon‐ditioning protects brain of rats by inhibiting apoptosis of neurons and inflammatory reaction .
Keywords：brain ischemiamiddle cerebral arteryhippocampusreperfusion injury
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 1201-1203 )