Prognostic value of pregnancy-associated plasma protein A in elderly patients with non-ST segment elevation acute coronary syndrome
Abstract：Objective To study the prognostic value of pregnancy‐associated plasma protein‐A (PAPP‐A ) in elderly patients with NSTEACS .Methods Four hundred and fifty‐five elderly NSTEACS patients were included in this study .Their serum PAPP‐A level was measured .The patients were followed up for 12 months ,during which the adverse cardiovascular events were ob‐served .The patients were divided into high PAPP‐A group (n=147)and low PAPP‐A group (n=308) .The association between serum PAPP‐A level and adverse cardiovascular events was ana‐lyzed .Results At the end of 12 months follow‐up ,the incidence of combined endpoint events was significantly higher in high PAPP‐A group than in low PAPP‐A group (57 .7% vs 24 .4% ,P=0.000) .The sensitivity and specificity of PAPP‐A were 66 .7% and 75.0% for predicting adverse cardiovascular events when it was 23 .5 mU/L .The elevated PAPP‐A level was significantly asso‐ciated with adverse cardiovascular events (OR= 2 .832 ,P=0.006) .The elevated PAPP‐A level was an independent risk factor for poor prognosis (HR=2 .79 ,P=0 .007) .Conclusion PAPP‐A is an effective indicator of prognosis in elderly NSTEACS patients and can thus be used in assess‐ment of risk factors for their poor prognosis .
Keywords：pregnancy-associated plasma protein-Aacute coronary syndromeROC curverisk fac-torsprognosis
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 1151-1154 )