Aspirin resistance in elderly cardiovascular disease patients with hyperhomocysteinaemia and its risk factors
Abstract：Objective To study the aspirin resistance (AR) in elderly cardiovascular disease (CVD) patients with hyperhomocysteinaemia (Hhcy) and its risk factors .Methods Three hundred and seventy elderly CVD patients were divided into Hhcy group (n= 216) and control group (n=154) .The patients received conventional aspirin therapy (≥75 mg)over 1 month .The therapeutic effect of aspirin was assessed according to the platelet aggregation rate detected by light turbidim‐etry .AR was defined when the arachidonic acid‐induced platelet aggregation rate was ≥ 20% . Results The prevalence of AR was significantly higher in Hhcy group than in control group (16.7% vs 7 .8% ,P=0 .012) .The serum Hcy and creatinine levels were significantly higher in Hhcy group than in control group (P<0 .05 ,P<0 .01) .Hhcy was an independent risk factor for AR(OR=2.406 ,95% CI:1 .201-4 .820 ,P=0 .013) .Conclusion The prevalence of AR is signifi‐cantly higher in elderly CVD patients with Hhcy which is an important risk factor for AR .
Keywords：cardiovascular diseaseshyperhomocysteinemiaaspirinplatelet aggregation
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 1140-1143 )