Oxidative stress and risk factors for carotid atherosclerosis in population at high risk of ischemic stroke
Abstract：Objective To analyze the risk factors for CAS by investigating the relation between oxi‐dative stress and CAS in population at high risk of ischemic stroke in Fuquan County of Guizhou Province .Methods One thousand and thirty two individuals at high risk of ischemic stroke were screened from 9500 permanent residents of Fuquan County by questionarie investigation ,physical examination ,laboratory test ,ECG and neck vascular color ultrasonography .Three hundred and sixty randomly selected from the 1032 individuals were divided into normal carotid artery group (n=78) ,thickened carotid IM T group (n=131) and CAS group (n=151) .Their serum ox‐LDL and SOD levels were measured and the risk factors for their CAS were analyzed by univariate and multivariate logistic regression analysis respectively .Results The serum ox‐LDL level was signif‐icantly higher while the serum SOD level was significantly lower in CAS group than in normal ca‐rotid artery group and thickened carotid IM T group (P<0 .05) .Univariate and multivariate logis‐tic regression analysis showed that age ,smoking ,hypertension ,history of ischemic stroke ,and ele‐vated serum FPG ,LDL‐C ,ox‐LDL levels were the independent risk factors for CAS .Conclusion Good management of population at high risk of ischemic stroke ,active control of risk factors for CAS and oxidative stress can delay the progression of CAS and reduce the incidence of ischemic stroke .
Keywords：strokeoxidative stresscarotid artery diseasesatherosclerosislipoproteinsLDLsu-peroxide dismutaserisk factors
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 1125-1128 )