Role of promoting blood circulation and its combination with detoxication in protecting AMI rats against myocardial injury
Abstract：Objective To study the role of promoting blood circulation and its combination with de‐toxication in protecting AMI rats against myocardial injury .Methods One hundred male SD rats were randomly divided into sham operation group ,model group ,promoting blood circulation group ,promoting blood circulation and detoxication group ,and metoprolol treatment group (20 in each group) .The animals were sacrificed 24 h after a model of AMI was established .Their myo‐cardial tissue lesions were observed by optical microscopy ,their myocardial infarction size was measured by TIC ,their serum levels of CK‐MB ,cTnI ,ET‐1 ,vWF ,and TM were measured by ELISA .Results The myocardial infarction size was significantly larger and the serum levels of CK‐MB ,cTnI ,ET‐1 ,vWF ,and TM were significantly higher in model group than in sham opera‐tion group (P<0 .01) .The serum levels of cTnI ,ET‐1 and vWF were significantly lower in pro‐moting blood circulation and detoxication group than in metoprolol treatment group ( P<0 .05 , P<0 .01) .The serum levels of cTnI ,ET‐1 ,vWF ,and TM were improved more signficantly in promoting blood circulation and detoxication group than in promoting blood circulation group (P<0 .05 ,P< 0 .01) .Conclusion Combined promoting blood circulation and detoxication can protect AMI rats against myocardial injury ,and its effect is significantly better than that of simple promoting blood circulation to remove blood stasis .
Keywords：myocardial infarctionBLOOD ACT STASIS REMOVtroponin Iendothelin-1meto-prololCOMPATIBILITY(TCD)
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 960-963 )