Application of MRI in identifying the onset time of wake-up ischemic stroke
Abstract：Objective Mismatch in lesion visibility between diffusion‐weighted image (DWI) and fluid‐attenuated inversion recovery (FLAIR) has been proposed as a biomarker for the estimation of ischemic lesion age .To compare the MRI features of wake‐up ischemic stroke and clear‐onset time stroke ,and to identify the role of DWI‐FLAIR mismatch in determing the onset time of wake‐up stroke .Methods Two hundred patients with acute ischemic stroke were divided into wake‐up stroke group (n=87) and clear‐onset time stroke group (n=113)according to the onset time of their disease .Their general condition and image characteristics were recorded .The DWI‐FLAIR mismatch at different time points was compared between the two groups .Results No sig‐nificant difference was found in the DWI‐FLAIR mismatch between the two groups (50 .0% vs 70 .0% ,P=0 .181) .The DWI‐FLAIR mismatch decreased sharply in wake‐up stroke group with the increasing time .The proportion of patients with DWI‐FLAIR mismatch in clear‐onset time stroke group was still high within 4 .0 hours from the abnormal to MRI times .The DWI‐FLAIR mismatch was significantly lower in wake‐up stroke group than in clear‐onset time stroke group at 2.1-3.0,3.1-4.0,4.1-5.0h(13.6% vs60.7% ,9.5% vs47.8% ,5.9% vs45.0% ,P<0.05, P<0 .01) .The neurological dysfunction score was a predictor of DWI‐FLAIR mismatch .Conclu‐sion wake‐up stroke patients can be treated with thrombolytic therapy .
Keywords：arousalstrokemagnetic resonance imagingtime factors
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 915-918 )