Relation of diabetic nephropathy and blood glucose fluctuation with inflammatory factors
Abstract：Objective To study the relation of diabetic nephropathy and blood glucose fluctuation with inflammatory factors .Methods One hundred and nine T2DM patients with their 72 h blood glucose dynamically monitored were divided into macroalbuminuria group (group A ,n=36) ,mi‐croalbuminuria group (group B ,n=35) and normal albuminuria group (group C ,n=38) according to their urinary albumin excretion rate (UAER) .Thirty subjects undergoing physical examination served as a control group .The patients were treated with insulin for 12 weeks .Their FPG ,FINS , HbA1c ,MAGE ,IL‐6 ,TNF‐α ,and UAER were measured before and after treatment .Results The serum levels of FPG ,TG ,HbA1c were significantly lower in groups A ,B and C after treatment than before treatment (P<0 .05) .The serum levels of IL‐6 ,TNF‐α,MACE and UAER were sig‐nificantly lower in groups A and B after treatment than before treatment (P<0 .05 ,P<0 .01) . The MAGE was positively related with the UAER ,IL‐6 and TNF‐α (r=0 .392 ,P=0 .013 ;r=0.587 ,P=0 .002 ;r=0 .659 ,P=0 .000) .The age ,disease duration ,systolic blood pressure ,and se‐rum levels of HbA1c ,IL‐6 ,TNF‐αand MAGE were the risk factors for proteinuria in T2DM pa‐tients .Conclusion Blood glucose fluctuation is closely related with inflammatory factors which are involved in the occurrence and progress of diabetic nephropathy .
Keywords：diabetic nephropathiesdiabetes mellitustype 2albuminuriainterleukin-6tumor nec-rosis factor-alphainsulinblood glucose
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 273-276 )