Change of inflammatory factor levels in patients with acute coronary syndrome and its clinical significane
Abstract：Objective To study the change of IL‐35 ,YKL‐40 and APN levels in patients with acute coronary syndrome and its clinical significance .Methods One hundred and seventeen coronary heart disease (CHD)patients were divided into acute myocardial infarction (AMI)group (n=40) , unstable angina pectoris (UAP) group (n= 40) ,stable angina pectoris (SAP) group (n= 37) . Thirty patients with chest pain and normal angiography served as a control group .The 117 CHD patients were further divided into mild CHD group with its Gensini score<26 (n=44) ,moderate CHD group with its Gensini score being 26 -54 (n=40)and severe CHD group with its Gensini score>54 (n= 33) .Theier serum IL‐35 ,YKL‐40 and APN levels were measured by ELISA . Results The serum IL‐35 and YKL‐40 levels were significantly higher whereas the serum IL‐35 and APN levels were significantly lower in SAP group ,UAP group and AMI group than in con‐trol group (P<0 .05 ,P<0 .01) .The serum APN level was negatively related with the Gensini score (r= -0 .844 ,P< 0 .01) ,the serum IL‐35 level was not related with the Gensini score (r= -0 .033 ,P= 0 .726) ,and the serum YKL‐40 level was positively related with the Gensini score (r=0 .814 ,P<0 .01) .Conclusion The significantly lower serum IL‐35 and APN levels and significantly higher serum YKL‐40 level indicate the severity of CHD at a certain extent ,and can thus be used as predictors for the diagnosis and prognosis of CHD .
Keywords：acute coronary syndromeatherosclerosisinterleukinsadiponectinT-lymphocytescy-tokines
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 253-257 )