Value of Cog-12 in predicting cognitive impairment in the elderly

doi:10.3969/j.issn.1009-0126.2015.03.004

Abstract：Objective To study the value of Cog‐12 in predicting cognitive impairment in the elder‐ly .Methods At the beginning ,56 individuals were enrolled into this study including mild cogni‐tive impairment (MCI) patients and normal cognitive function individuals‐involving a control group (n=18) ,11 patients with normal cognitive function who converted to MCI patients served as a CM group ,10 MCI patients with their MCI maintaining stable during the 2‐years follow‐up period served as MM group ,11 MCI patients who converted to AD patients served as an AD group .The patients were scored according to Cog‐12 ,MoCA and MMSE ,and their cognitive function was assessed at admission and after two years of follow‐up .Results The MoCA and MMSE scores were significantly higher whereas the Cog‐12‐Ⅰ score was significantly lower in control group than in CM group (P<0 .05) .The MoCA score was significantly higher whereas the total Cog‐12‐Ⅰ and Cog‐12 scores were significantly lower in MM group than in AD group (P<0 .05) .The Cog‐12 score was a predicting factor for MCI in patients with normal cognitive function (P=0.029) .The area under ROC curve showed that the sensitivity of Cog‐12 score in predicting MCI was 81 .4% when its cutoff value was 4 .5 .Conclusion Cog‐12 is an effective tool for assessing the intelligence ,mental state and behaviors of cognitive impairment patients and can thus predict their cognitive impairment .