Effect of intensive statin therapy on symptomatic intracranial artery stenosis
Abstract：Objective To observe the effect of intensive statin therapy on symptomatic intracranial artery stenosis (ICAS) .Methods One hundred and twenty symptomatic ICAS patients were ran-domly divided into group A ,group B and group C (40 in each group) .The patients in 3 groups were treated with atorvastatin at the dose of 10 mg/d ,20 mg/d ,and 40 mg/d ,respectively ,for at least 12 months .The patients were followed up for 12 months ,during which the incidence of car-diovascular events and perfusion of ischemic brain tissues were observed .The effect of intensive statin therapy on symptomatic ICAS was assessed .Results The incidence of cardiovascular events was 26 .3% ,13 .5% and 5 .4% ,respectively ,in groups A-C after 12 months of atorvastatin treatment ,and significantly higher in group A than in group C (26 .3% vs 5 .4% ,P<0 .05) .The rCBF and rCBV were significantly higher in groups A-C after treatment than before treatment (P<0 .05) .The rTTP was shorter in group C than in groups A and B (P<0 .05) .Conclusion Twelve-month intensive statin therapy (40 mg/d) can reduce the cerebrovascular events and im-prove the perfusion of ischemic brain tissues .
Keywords：intracranial arteriosclerosisantilipemic agentstreatment outcomeCT perfusion ima-ging
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 1048-1051 )