Correlation of heart function with plasma BNP and serum uric acid level in elderly heart failure patients
Abstract：Objective To study the correlation of heart function with plasma BNP and serum uric acid (UA) levels in elderly heart failure patients .Methods One hundred and thirty-two elderly patients with chronic heart failure (CHF)served as a CHF group in this study .They were divided into class Ⅰ group (n=26) ,class Ⅱ group (n=38) ,class Ⅲ group (n=40) ,and class Ⅳ group (n=28) according to the NYHA Classification .Fifty healthy subjects undergoing physical exami-nation served as a control group .Their plasma BNP and erum UA levels were measured and com-pared .Results The plasma BNP and erum UA levels were significantly higher in CHF group than in control group (784 .19 ± 206 .00 ng/L vs 41 .25 ± 15 .34 ng/L ,405 .24 ± 90 .16 μmol/L vs 286 .43 ± 78 .68 μmol/L ,P<0 .01) and were significantly different in class Ⅰ - Ⅳ groups (P<0.05 ,P<0 .01) .The plasma BNP level was positively correlated with the NYHA Classification , serum UA level and LVEDD ,and negatively correlated with the LVEF in CHF patients (r=0 .76 , 0 .33 ,0 .22 ,P<0 .05 ;r= -0 .34 ,P<0 .0 5) .The serum UA level was positively correlated with the NYHA Classification and LVEDD ,and negatively correlated with the LVEF in CHF patients (r=0 .41 ,0 .23 ,P<0 .05 ;r= -0 .24 ,P<0 .05) .Conclusion Plasma BNP and serum UA levels are correlated with the cardiac function classification in CHF patients .
Keywords：heart failurenatriuretic peptidebrainuric acidechocardiographyDoppler
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 1041-1043 )