Effect of pulse pressure on long-term kidney function in the elderly
Abstract：Objective To study the effect of PP on long-term kidney function in the elderly .Meth-ods A total of 9695 healthy people with their age ≥60 years who underwent physical examina-tion in our hospital were divided into PP< 40 mm Hg group (group 1 ,n= 972) ,PP= 40 -49 mm Hg group (group 2 ,n=2393) ,PP=50 -59 mm Hg group (group 3 ,n=2553) ,and PP≥60 mm Hg group (group 4 ,n=3777) .Impaired kidney function was defined when the eGFR was <60 ml/(min · 1 .73 m2 ) .The elderly were followed up for 24 -63 (50 .84 ± 4 .83) months .The effect of PP on long-term kidney function was analyzed using the Kaplan-Meier method and multi-variate Cox proportional hazard regression model .Results Impaired kidney function was detected in 352 of the followed up elderly ,namely in 11 of group 1 ,in 71 of group 2 ,in 81 of group 3 ,and in 189 of group 4 (1.1% vs 3 .0% vs 3.2% vs 5 .0% ,P<0 .01) .After adjustment for traditional risk factors ,the relative risk coefficient was 2 .67 (95% CI:1 .33-5 .38) ,2 .98 (95% CI:1 .49-5 .96) , and 4 .90 (95% CI:2 .50-9 .63) ,respectively ,in groups 2-4 ,which was higher than that in group 1 (P<0 .01) .Conclusion PP is an independent risk factor for impaired kidney function in the eld-erly .New kidney funtion impairment increases with the increasing PP .
Keywords：glomerular filtration raterenal insufficiencyblood pressurerisk factors
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 1038-1040 )