Protective effect of dietary restriction on cardiac function in aging rats
Abstract：Objective To study the protective effect of dietary restriction on cardiac function in ag-ing rats .Methods Ten SD rats aged 2 months were randomly divided into aging group and dieta-ry restriction (60% food intake) group (5 in each group) .An aging rat model was established by daily subcutaneous injection of D-galactose (100 mg/kg) for 42 days .Another 5 SD rats aged 2 months served as an adolecent group .The cardiac functions (including LVSP ,LVEDP ,+dp/dtmax ) were detected and the plasma MDA level ,SOD activity ,left ventricular myocardial li-pofuscin level were measured in 3 groups .Results The LVSP ,+dp/dtmax ,SOD activity were sig-nificantly lower while the LVEDP ,plasma MDA level ,myocardial lipofuscin level were signifi-cantly higher in aging group than in adolecent group (P<0 .05 ,P<0 .01) .The LVSP ,+dp/dtmax , SOD activity were significantly higher while the LVEDP ,plasma MDA level ,myocardial lipofuscin level were significantly lower in dietary restriction group than in aging group (110 .88 ± 7 .35 mmHgvs70.18±19.27mmHg,2827.60±237.88mmHg/svs2365.66±99.81mmHg/s, 115.77 ± 10 .17 U/ml vs 90 .10 ± 17 .11 U/ml ,7 .12 ± 2 .51 mm Hg vs 14 .05 ± 2 .01 mm Hg ,12 .54 ± 1 .66 nmol/ml vs 15 .83 ± 2 .51 nmol/ml ,348 .82 ± 27 .29 ng/mg vs 400 .12 ± 31 .89 ng/mg ,P<0.05 ,P<0 .01) .Conclusion The cardiac function decreases in aging rats .Dietary restriction can imporve their cardiac function by reducing the oxidative stress level and lipofuscin formation .
Keywords：oxidative stresslipofuscinmalondialdehydesuperoxide dismutasecell aging
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 964-966 )