Association of adiponectin level with MACCE and survival rate in elderly patients on hemodialysis

doi:10.3969/j.issn.1009-0126.2014.09.011

Abstract：Objective To study the association of serum adiponectin (APN) level with MACCE andsurvival rate in elderly patients on hemodialysis .Methods Seventy-nine elderly patients on hemodialysiswere enrolled in this study .Their APN level was measured .The patients were divided intoAPN ≥ 5 mg/L group (n= 44) and APN < 5 mg/L group (n = 35) .The patients were followed upfor 3 years during which the time and reasons of death were recorded .Their MACCE-free survivalrate was analyzed with the Kaplan-Meier method .The effect of APN level and other factors ontheir long-term outcome was analyzed by Cox regression analysis .Results MACCE occurred 25times/cases in APN < 5 mg/L group during the follow-up .The MACCE-free survival rate was77. 1% ,65 .7% ,42 .9% and 28 .6% for 6 ,12 ,24 and 36 months ,respectively .The ANP level decreasedgradually ,especially in 24 and 36 months ( P < 0 .01) .MACCE occurred 18 times/cases inANP ≥ 5 mg/L group during the follow-up .Their MACCE-free survival rate was 88 .6% ,72 .7% ,59 .1% and 38 .6% was for 6 ,12 ,24 and 36 months ,respectively .No significant change was foundin their APN level(P > 0 .05) .Survival analysis showed that the survival rate was different in twogroups ( P < 0 .01) .Cox univariate analysis showed that ANP level was an independent risk factorfor the long-term outcome in elderly patients ( P < 0 .05) .Conclusion The incidence of MACCEincreases with the decreasing APN level in those with their APN < 5 mg/L .APN level can be usedas a predictor for MACCE and long-term survival rate in elderly patients on hemodialysis .