Relationship of ACE2350G/A and chymase genetic polymorphisms with hypertensive left ventricular hypertrophy
Abstract：Objective To study the distribution of ACE2350G/A and chymase gene polymorphisms in hypertensive patients with left ventricular hypertrophy (LVH) and subjects undergoing physi-cal examination ,and the molecular genetic mechanism of hypertensive LV H .Methods Hyperten-sive in-patients were divided into LVH group and essential hypertension group ,and subjects un-dergoing physical examination served as a control group .Their ACE2350G/A and chymase gene polymorphisms were detected by PCR-RFLP .Results The frequency of AA genotype and A al-lele of ACE2350 gene was significantly higher in LVH group than in control group (25 .7% vs 13.9% ,51 .4% vs 39 .6% ,P<0 .05) .However ,no significant difference was found in the frequen-cy of G and A allele of CMA/B gene between the two groups (P>0 .05) .Conclusion ACE2350 gene polymorphism is closely related with LVH .AA genotype increases the risk of LVH ,and A allele is the risk factor for LVH .CMA/B gene is not related with hypertensive LVH .
Keywords：peptidyl-dipeptidase Achymaseshypertensionhypertrophyleft ventriculargenotype
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 912-915 )