Plasma antioxidative stress parameters levels in patients with early and delayed Parkinson's disease
Abstract：Objective To study the difference in plasma antioxidative stress parameters levels in patients with early and delayed Parkinson's disease (PD) and its relation with the clinical features of PD .Methods Sixty-two primary PD patients served as a PD group which was further divided into early PD group (n=35) and delayed PD group (n=27) ,and 20 subjects undergoing physical examination served as a control group .Their plasma GSH ,CAT ,SOD and GPX levels were meas-ured by ELISA .The difference in different groups was compared and the relation between disease onset age and plasma antioxidative parameters levels was analyzed .Results The plasma GSH , CAT and SOD levels were significantly lower in PD group than in control group (18 .42 ± 14 .64μmol/L vs79.32±64.48 μmol/L,160.87±10.49kU/L vs171.11±4.00kU/L,93.58±24.17 kU/L vs 122 .33 ± 22 .83 kU/L ,P<0 .01)whereas the plasma GSH level was significantly higher in early PD group than in delayed PD group (P<0 .05) .The disease onset age was negatively re-lated with the plasma GSH level (P< 0 .01) .Conclusion The significantly low plasma GSH , CA T and SOD levels in PD patients suggest that the antioxidant capacity is insufficient in PD pa-tients .The plasma GSH level differs greatly in early and delayed PD patients .The older the dis-ease onset age is ,the lower the plasma GSH level is .
Keywords：Parkinson diseaseage factorsoxidative stresscatalasesuperoxide dismutasegluta-thioneglutathione peroxidase
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 903-905 )