Dynamic change of bili rubin and P-selectin in elderly ischemic stroke patients and its clinical significance
Abstract：Objective To study the dynamic change of bilirubin and P-selectin in elderly acute is-chemic stroke (AIS) patients at different time points and at different conditions of disease and its clinical significance .Methods Ninety-eight ischemic stroke (IS)patients were divided into mild IS group (n=38) ,moderate IS group (n=35) and severe IS group (n=25) according to their nerve function score ,and 30 healthy subjects undergoing physical examination served as a control group .Their serum levels of P-selectin ,bilirubin and hs-CRP were measured on days 1 ,3 ,7 and 14 respectively after onset of IS .Results The serum levels of P-selectin ,hs-CRP ,total and indirect bilirubin were significantly higher in different IS groups than in control group ,in moderate and se-vere IS groups than in mild IS group on days 1 ,3 ,7 after onset of IS (P<0 .05) .The serum P-se-lectin level was significantly higher in moderate and severe IS groups than in control group on day 14 after onset of IS (78 .2 ± 15 .0 ng/L ,107 .1 ± 24 .3 ng/L ,91 .5 ± 21 .1 ng/L ,85 .5 ± 18 .5 ng/L , 135.2±34.0ng/L,99.3±27.0ng/L vs48.8±6.7ng/L,86.0±10.9ng/L,72.5±11.3ng/L, P<0 .05) .Conclusion P-selectin and bilirubin may be involved in the pathogenesis of IS .Meas-urement of serum P-selectin and bilirubin level contributes to the early diagnosis and treatment of IS and assessment of its prognosis .
Keywords：brain infarctionbilirubinP-selectinC-reactive proteinearly diagnosis
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 826-829 )