Effect of glutathione system on coronary artery lesion in type 2 diabetes mellitus patients
Abstract：Objective To study the effect of glutathione (GSH)system on coronary artery lesion in type 2 diabetes mellitus (T2DM)patients .Methods Two hundred and thirty-six patients who un-derwent coronary angiography were divided into normal glucose tolerance (NGT ) group (n=126) and T2DM group (n= 110) .Their biochemical indexes were assayed and serum levels of GSH , GSH-Px and GR were meausred .Their coronary artery lesion was scored according to the Gensini scoring system .Results The serum levels of GSH ,GSH-Px and GR were significantly lower in T2DM group than in NGT group (3 .87 ± 1 .55 μg/L vs 4 .45 ± 1 .94 μg/L ,0 .29 ± 0 .05 ng/L vs 0.35 ± 0 .08 ng/L ,0 .19 ± 0 .07 ng/L vs 0 .26 ± 0 .08 ng/L ,P<0 .05) and negatively related with the Gensini score after adjustment for age ,BMI ,blood pressure ,blood lipids ,fasting glucose and insulin ,postprandial 2 h glucose and insulin ,HbA1c (P<0 .05 ,P<0 .01) ,indicating that the ser-um levels of GSH ,GSH-Px and GR could significantly influence the Gensini scores in T 2DM pa-tients .Conclusion Low serum levels of GSH ,GSH-PX and GR are negatively related with coro-nary artery lesion and are the independent factors for coronary artery lesion in T 2DM patients .
Keywords：glutathionediabetes mellitustype 2coronary artery diseasecoronary angiographyapoptosisperoxidase
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 805-807 )