Effect of melatonin on MMP expression and neurological function in rats following intracerebral hemorrhage
Abstract：Objective To observe the effect of melatonin (MT) on neurological function and MMP2/9 expression in rats following intracerebral hemorrhage (ICH) .Methods Eighty-five SD rats were randomly divided into normal group (n=10) ,sham operation group(n=25) ,ICH model group (n= 25) and MTintervention group (n= 25) .Rats in ICH model group ,sham operation group and MTintervention group were divided into 12h group ,1d group ,2d group ,4d group and 7d group (5 in each group) .Their neurological function was assessed according to the modi-fied NSS .Morphology of microvascular structure was observed under electron microscope .Ex-pression of MMP2/9 mRNA was detected by RT-PCR .Results The NSS score was significantly lower in MTintervention group than in model group on days 1-7 after ICH (P<0 .05) .The ex-pression level of MMP2 mRNA was significantly higher in MT intervention group than in model group from 12h to 4d after ICH and significantly lower on day 7 after ICH (P<0 .05) .The ex-pression level of MMP9 mRNA increased significantly in model group on day 2 after ICH and reached its peak in MT intervention group on day 1 after ICH .The expression level of MMP9 mRNA was significantly higher in MTintervention group than in model group on day 7 after ICH (P<0 .05) .Conclusion MTimproves the neurological function in rats following ICH by regula-ting the MMP2/9 expression and alleviating the vasogenic brain edema .
Keywords：melatonincerebral hemorrhagematrix metalloproteinaseshematoma
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 641-645 )